職稱/職務(wù):副研究員/碩士生導(dǎo)師
學(xué)歷/學(xué)位:研究生/博士
工作電話:0510-68781032
電子郵箱:hxq_821@163.com
何小芹,副研究員,現(xiàn)任職于江蘇省血吸蟲(chóng)病防治研究所。2009年獲鹽城師范生物技術(shù)專業(yè)學(xué)士學(xué)位,2014年獲南京農(nóng)業(yè)大學(xué)微生物學(xué)博士學(xué)位。2014—2016年在中科院昆明動(dòng)物研究所從事博士后研究。2016年12月起,一直在江蘇省血吸蟲(chóng)病防治研究所學(xué)習(xí)工作。主要從事寄生蟲(chóng)病的相關(guān)科研工作。曾主持國(guó)家自然基金青年項(xiàng)目,參加國(guó)家自然基金面上,先后以一作或共一作發(fā)表SCI文章8篇。
2019.12—至今 江蘇省血吸蟲(chóng)病防治研究所,副研究員,碩士生導(dǎo)師
2016.10—2019.12 江蘇省血吸蟲(chóng)病防治研究所,博士后
2014.08—2016.08 中國(guó)科學(xué)院昆明動(dòng)物研究所,博士后
2010.06—2014.06 中國(guó)科學(xué)院昆明動(dòng)物研究所,從事天然多肽/蛋白/化合物的發(fā)掘、功能與作用機(jī)理研究
2009.09—2014.06 南京農(nóng)業(yè)大學(xué)生科院,微生物學(xué),博士研究生
2005.09—2009.07 鹽城師范學(xué)院生科院,生物技術(shù),獲理學(xué)學(xué)士
一、論文(論著)發(fā)表情況
1Xiaoqin He?, Chuanbin Shen?, Qiumin Lu?, Jiong Li, Yuquan Wei, Li He, Ruizhen Bai, Jie Zheng, Ning Luan, Zhiye Zhang, Mingqiang Rong*and Ren Lai*. Prokineticin 2 Plays a Pivotal Role in Psoriasis. EBioMedicine.2016 Nov; 13: 248–261. doi: 10.1016/j.ebiom. 2016. 10.022
2.Xiaoqin He?, Yang Yang1?, Lixian Mu?, Yandong Zhou1?, Yue Chen1, Jing Wu,Yipeng Wang, Hailong Yang, Min Li , Wei Xu* and Lin Wei. A Frog-Derived Immunomodulatory Peptide Promotes Cutaneous Wound Healing by Regulating Cellular Response. Immunol. 10:2421.doi: 10.3389/fimmu.2019.02421
3.Jiajia Chang ?, Xiaoqin He?, Jingmei Hu ?, Peter Muiruri Kamau, Ren Lai,Dingqi Rao,* and Lei Luo*. Bv8-Like Toxin from the Frog Venom of Amolops jingdongensis PromotesWound Healing via the Interleukin-1 Signaling Pathway, Toxins 2020, 12, 15; doi:10.3390/ toxins 12010015
4.Yaqun Fang ?, Xiaoqin He ?, Pengcheng Zhang ?, Chuanbin Shen, James M wangi,Cheng Xu, Guoxiang Mo, Ren Lai,* and Zhiye Zhang.In Vitro and In Vivo Antimalarial Activity of LZ1, a Peptide Derived from Snake Cathelicidin, Toxins 2019, 11, 379; doi:10.3390/toxins11070379.
5.Yang Yang#, Zhen Liu#, Xiaoqin He#, Juanjuan Yang, Jing Wu, Hailong Yang, Min Li, Qian Qian, Ren Lai,*, Wei Xu,*, Lin Wei. A small mycobacteriophage-derived peptide and its improved isomer restrict mycobacterial infection via dual mycobactericidal-immunoregulatory activities, J. Biol. Chem. 2019 05 10;294(19) DOI:10.1074/jbc.RA118.006968
6.Xu C#, He X#, Liu W, Chen Y, Zhou C, Duan Z, Lu Q, Yan X, Zhang Z, Zheng R*. An inhibitor peptide of toll-like receptor 2 shows therapeutic potential for allergic conjunctivitis, InternationalImmunopharmacology, 2017, 46:9-15
7.He X# , Yang S# , Wei L, Liu R, Lai *, Rong M*, Antimicrobial peptide.diversity in the skin of the torrent frog, Amolops jingdongensis, Amino Acids,2013, 44(2): 481-487
8.Wei, L#,Yang, J#,He X#,Mo G, Hong J, Yan X,Lin Di*,Lai R*,Structure and function of a potent lipopolysaccharide-binding antimicrobial and anti-inflammatory peptide, Journal of Medicinal Chemistry, 2013, 56(9):3546-3556
9.Shang X, Shen S, Tang J, He X, Zhao Y, Wang C, He X, Guo G, Liu M, Wang L, Zhu Q, Yang G, Jiang C, Zhang M, Yu X, Han J, Culleton R, Jiang L, Cao J, Gu L, Zhang Q. A cascade of transcriptional repression determines sexual commitment and development in Plasmodium falciparum. Nucleic Acids Res. 2021 Sep 20;49(16):9264-9279. doi: 10.1093/nar/gkab683. PMID: 34365503; PMCID: PMC8450074.
10.Fan Y, Shen S, Wei G, Tang J, Zhao Y, Wang F, He X, Guo G, Shang X, Yu X, Ma Z, He X, Liu M, Zhu Q, Le Z, Wei G, Cao J, Jiang C, Zhang Q. Rrp6 Regulates Heterochromatic Gene Silencing via ncRNA RUF6 Decay in Malaria Parasites. mBio. 2020 Jun 2;11(3):e01110-20. doi: 10.1128/mBio.01110-20. PMID: 32487761; PMCID: PMC7267889.
二、專利情況
1.衛(wèi)林;何小芹;楊洋;徐薇,一種凹耳蛙免疫調(diào)節(jié)肽及其應(yīng)用2020年12月29日 專利號(hào):ZL 2019 1 0935233.3
2.衛(wèi)林; 武靜; 徐薇, 何小芹一種天蠶素衍生肽的應(yīng)用2018.11.6 中國(guó)201811627640X
3.衛(wèi)林; 徐薇; 周延?xùn)|,何小芹一種固有免疫激活肽的應(yīng)用2018.11.3 中國(guó)201811308280.7
4.賴仞; 何小芹Prokineticin 2作為銀屑病生物標(biāo)志物及其應(yīng)用2016.10.8中國(guó), 201610804908.7
三、承擔(dān)科研項(xiàng)目情況
1.國(guó)家自然科學(xué)基金委員會(huì),青年基金項(xiàng)目,81603080,兩種景東湍蛙抗菌肽新家族的抗菌功能與作用機(jī)制研究,2017.01—2018.12,19 萬(wàn)元,已結(jié)題,主持
2.國(guó)家自然科學(xué)基金委員會(huì),面上項(xiàng)目,81772230,中華按蚊主效抗性分子CYP4H14在菊酯殺蟲(chóng)劑抗性中的作用機(jī)制研究,2018.01—2019.12,25萬(wàn)元,已結(jié)題,參與