職稱/職務(wù):副研究員/青年P(guān)I
學(xué)歷/學(xué)位:研究生/博士
工作電話:0510-68781016
電子郵箱:songlijun1025@163.com
宋麗君,副研究員,2011年獲江蘇省血吸蟲病防治研究所醫(yī)學(xué)碩士,2021年獲南京大學(xué)理學(xué)博士,現(xiàn)就職于江蘇省血吸蟲病防治研究所創(chuàng)新團(tuán)隊(duì)。江蘇省血吸蟲病防治研究所碩導(dǎo),南京醫(yī)科大學(xué)兼職碩導(dǎo),主要從事血吸蟲病感染免疫、診斷與治療的研究。以第一/共同第一作者在Signal Transduction and Targeted Therapy,F(xiàn)rontiers in Immunology,Parasites & Vectors等國(guó)際知名期刊發(fā)表SCI論文9篇,單篇最高影響因子38.1。獲江蘇醫(yī)學(xué)科技獎(jiǎng)二等獎(jiǎng)、江蘇省預(yù)防醫(yī)學(xué)會(huì)科技獎(jiǎng)二等獎(jiǎng)、江蘇省衛(wèi)生計(jì)生委醫(yī)學(xué)新技術(shù)引進(jìn)獎(jiǎng)二等獎(jiǎng)。主持國(guó)家自然科學(xué)基金青年項(xiàng)目、江蘇省衛(wèi)健委面上項(xiàng)目、無錫市衛(wèi)健委青年項(xiàng)目等4項(xiàng),參與國(guó)家和省自然科學(xué)基金項(xiàng)目5項(xiàng),獲得發(fā)明專利5項(xiàng)。擔(dān)任所青年P(guān)I,《中國(guó)熱帶醫(yī)學(xué)》雜志青年編委。
2003.09—2008.07 華北煤炭醫(yī)學(xué)院預(yù)防醫(yī)學(xué)專業(yè)學(xué)習(xí),獲醫(yī)學(xué)學(xué)士學(xué)位
2008.09—2011.07 江蘇省血吸蟲病防治研究所病原生物學(xué)專業(yè)學(xué)習(xí),獲醫(yī)學(xué)碩士學(xué)位
2016.09—2021.09 南京大學(xué)生命科學(xué)學(xué)院藥學(xué)專業(yè)學(xué)習(xí),獲理學(xué)博士學(xué)位
2011.07—今 江蘇省血吸蟲病防治研究所工作
一、論文(論著)發(fā)表情況
1. Song, Li-Jun; Yin, Xu-Ren; Guan, Sheng-Wen; Gao, Hong; Dong, Pan-Pan; Mei, Cong-Jin; Yang, Ying-Ying; Zhang Ying; Yu,Chuan-Xin; Hua, Zi-Chun; RIP3 deficiency attenuated hepatic stellate cell activation and liver fibrosis in schistosomiasis through JNK-cJUN/Egr1 downregulation. Signal Transduct Target Ther. 2022, 7(1):193.
2. Song, Li-Jun; Yin, Xu-Ren; Mu, Sha-Sha; Li, Jia-Huang; Gao, Hong; Zhang, Ying; Dong, Pan-Pan; Mei, Cong-Jin; Hua, Zi-Chun ; The Differential and Dynamic Progression of Hepatic Inflammation and Immune Responses During Liver Fibrosis Induced by Schistosoma japonicum or Carbon Tetrachloride in Mice, Frontiers in Immunology, 2020, 11: 570524.
3. Song, Li-Jun; Li, Jia-Huang; Yin, Xu-Ren; Zhang, Wei; Jin, Yi; Gao, Hong; Wang, Jie; Yu,Chuan-Xin; Hua, Zi-Chun; Identification of Peptide Antagonists to Thioredoxin Glutathione Reductase of Schistosoma japonicum, Biomed Research International, 2018, 2018: 9483928.
4. Wang, Wen-Long; Song, Li-Jun(co-first author); Hu, Bo-Chun; Miao, Li; Chen, Xiao-Yu; Fan, Wen-Hua; Yin, Xu-Ren; Shen, Shuang; Ding, Zhao-Feng; Yu, Chuan-Xin ; Decoquinate derivatives: A new class of potent antischistosomal agents against Schistosoma japonicum, Chinese Chemical Letters, 2017, 28(7):1547-1552.
5. Song, Li-Jun; Luo, Huan; Fan, Wen-Hua; Wang, Gu-Ping; Yin, Xu-Ren; Shen, Shuang; Wang, Jie; Jin, Yi; Zhang, Wei; Gao, Hong; Liu, Qian; Wang, Wen-Long; Feng, Bainian; Yu, Chuan-Xin ; Oxad iazole-2-oxides may have other functional targets, in addition to SjTGR, through which they causemortality in Schistosoma japonicum, PARASITES & VECTORS, 2016, 9.
6. Wen-Long Wang, LiJun Song(co-first author), XiaoYu Chen, Chao Huang, XuRen Yin, Shuang Shen, ChuanXin Yu. Synthesis of Triclabendazole Derivatives and Biological Evaluation Against Schistosoma japonicum. Lat. Am. J. Pharm. 2016, 35 (10): 2274-8.
7. FeiFei Yang, LiJun Song(co-first author), XuRen Yin, Shuang Shen, ChuanXin Yu, LuHong Tang. Activity of Gossypol against Schistosoma japonicum. Lat. Am. J. Pharm. 2016, 35 (7):1-4.
8. Wen-Long Wang, Li-Jun Song(co-first author), Xia Chen, Xu-Ren Yin, Wen-Hua Fan, Gu-Ping Wang, Chuan-Xin Yu* and Bainian Feng*. Synthesis and SAR Studies of Praziquantel Derivatives with Activity against Schistosoma japonicum. Molecules 2013, 18, 9163-9178.
9. Song, LiJun; Li, JiaHuang; Xie, ShuYing; Qian, ChunYan; Wang, Jie; Zhang, Wei; Yin, XuRen; Hua, ZiChun; Yu, ChuanXin ; Thioredoxin Glutathione Reductase as a Novel Drug Target: Evidencefrom Schistosoma japonicum, PLOS ONE, 2012, 7(2).
10. Xue-Dan Ke, Shuang Shen, Li-Jun Song, Chuan-Xin Yu, Mihoko Kikuchi, Kenji Hirayama, Hong Gao, Jie Wang, Xuren Yin, Yuan Yao, Qian Liu, Wei Zhou. Characterization of Schistosoma japonicum CP1412 protein as a novel member of the ribonuclease T2 molecule family with immune regulatory function. Parasit Vectors, 2017, 10: 89.
二、承擔(dān)科研項(xiàng)目情況
1. 國(guó)家自然科學(xué)基金青年項(xiàng)目,81802035,RIP3調(diào)控的細(xì)胞程序性壞死在血吸蟲病肝纖維化中的作用及其分子機(jī)制,主持。
2. 國(guó)家自然科學(xué)基金面上項(xiàng)目,82173586,miR-383-5p及靶基因在新發(fā)晚期血吸蟲病肝纖維化中的作用機(jī)制與預(yù)警價(jià)值研究,參與。
3. 江蘇省衛(wèi)生計(jì)生委面上項(xiàng)目,H201635,日本血吸蟲童蟲早期診斷抗原分子的鑒定及其應(yīng)用研究,主持。
4. 無錫市衛(wèi)生計(jì)生委青年項(xiàng)目,Q201656,日本血吸蟲童蟲早期診斷抗原分子的鑒定及其應(yīng)用研究,主持。
5. 江蘇省血地寄課題,X201429,生物素-親和素系統(tǒng)檢測(cè)華支睪吸蟲抗原特異性IgG4抗體診斷方法的建立及其應(yīng)用效果的研究,主持。
三、發(fā)明專利情況:
1. 宋麗君,姚媛,余傳信,殷旭仁,沈雙,高玒. 抗日本血吸蟲硫氧還蛋白谷胱甘肽還原酶SjTGR單區(qū)抗體及其制備方法。專利號(hào):ZL201410285116.4。
2. 余傳信,馮柏年,宋麗君,王文龍. 一類1,2,5-噁二唑-2氧化物類似物、其制備方法和 用途。專利號(hào):ZL201310056992.5。
3. 余傳信,馮柏年,宋麗君,王文龍. 一類吡喹酮類似物制備方法和用途。專利號(hào):ZL201310007886.8。
4. 余傳信,金一,宋麗君,王玠,殷旭仁,沈雙. 一種預(yù)防血吸蟲感染長(zhǎng)效青蒿琥酯藥物及其制備方法。專利號(hào):ZL201310304323.5。
5. 余傳信, 王玠, 張偉, 錢春艷, 宋麗君, 殷旭仁, 梁幼生, 高琪 . 一種日本血吸蟲23kDa膜蛋白大親水肽段融合蛋白及其在血吸蟲感染免疫診斷中的應(yīng)用。專利號(hào):, ZL201110037374.7。
四、獲獎(jiǎng)情況:
1. 《江蘇省阻斷血吸蟲病傳播的關(guān)鍵技術(shù)研究與推廣應(yīng)用》獲2020年江蘇醫(yī)學(xué)科技獎(jiǎng)二等獎(jiǎng)。
2. 《日本血吸蟲病傳染源新型診斷方法的研究與應(yīng)用》獲2019年江蘇省預(yù)防醫(yī)學(xué)會(huì)科技獎(jiǎng)二等獎(jiǎng)。
3.《日本血吸蟲感染生物標(biāo)志物及其應(yīng)用研究》獲江蘇省衛(wèi)生計(jì)生委 2018 年度醫(yī)學(xué)新技術(shù)引進(jìn)獎(jiǎng)二等獎(jiǎng)。